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Lifelong choline supplementation in another Alzheimers disease mouse model (APP/PS1 transgenic mice), significantly diminished amyloid- plaque load and decreased activated microglia, thereby mitigating the detrimental effects of brain inflammation associated with Alzheimers disease (165)

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84,87 Another trial with 67 participants found a hops extract standardized to supply 100 mcg of 8-prenylnaringenin per day reduced hot flashes more than placebo after six weeks, but the difference between hops and placebo disappeared after 12 weeks